📄 Abstract
The present project focuses on the synthesis of Aspirin (acetylsalicylic acid) from Salicylic acid and the evaluation of its purity using standard pharmaceutical methods. Aspirin is a widely used non-steroidal antiinflammatory drug (NSAID) known for its analgesic, antipyretic, antiinflammatory, and antiplatelet properties. Due to its extensive therapeutic applications, the study of its preparation and quality assessment is of great importance in pharmaceutical sciences. The synthesis is carried out by an acetylation reaction in which salicylic acid reacts with acetic anhydride in the presence of an acid catalyst such as sulfuric acid or phosphoric acid. During this reaction, the phenolic hydroxyl group of salicylic acid is converted into an ester group, forming aspirin, while acetic acid is produced as a byproduct. The reaction is performed under controlled temperature conditions using a water bath to ensure proper completion. The crude product obtained is purified by recrystallization using ethanol to remove impurities and obtain pure aspirin crystals. The purity of the synthesized aspirin is evaluated using melting point determination, Ferric chloride test, and Thin Layer Chromatography (TLC). These analytical techniques help in confirming the identity and quality of the product. This project provides a clear understanding of drug synthesis, purification techniques, and quality control methods used in pharmaceutical chemistry
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📚 How to Cite:
Dnyaneshwar Narayan Ghuge , Mr. Datta G. Korde , TO SYNTHESIS ASPIRIN FROM SALICYLIC ACID AND EVALUATE ITS PURITY , Volume 13 , Issue 6, June 2026, EPRA International Journal of Socio-Economic and Environmental Outlook(SEEO) , Pages: 7 - 15 ,