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INVESTIGATION OF THE RELATIONSHIP BETWEEN VITAMIN B12 LEVEL, NEUROTRANSMITTER IMBALANCE, AND THE CLINICAL SEVERITY OF HEMIFACIAL SPASM

📘 Volume 11 📄 Issue 11 📅 November 2025

👤 Authors

Uzakov Jurabek Bakhtiyorovich, Boltaeva Shakhnoza Uktam kizi 1
1. Samarkand State Medical University, Samarkand, Medical rehabilitation, sports medicine and traditional medicine, Uzbekistan

📄 Abstract

The article is devoted to the study of metabolic and neurochemical factors influencing the pathogenesis of hemifacial spasm (HFS).The levels of vitamin B12, cortisol, and dopamine were determined in patients with HFS and compared with those in a control group. Significant correlations were established between decreased vitamin B12 levels, hyperactivity of the hypothalamic–pituitary–adrenal axis, and disturbances in neurotransmitter processes. The findings confirm the involvement of vitamin B12 deficiency in the disruption of neurovascular interactions, which contributes to the development of chronic pathological spasm of the facial muscles and defines directions for comprehensive patient rehabilitation.

🏷️ Keywords

Hemifacial Spasm Vitamin B12 Dopamine Cortisol Neurotransmitter Imbalance Metabolic Markers Neurovascular Dysfunction Rehabilitation

🔗 DOI

View DOI - (https://doi.org/10.36713/epra24895)

📚 How to Cite:

Uzakov Jurabek Bakhtiyorovich, Boltaeva Shakhnoza Uktam kizi , INVESTIGATION OF THE RELATIONSHIP BETWEEN VITAMIN B12 LEVEL, NEUROTRANSMITTER IMBALANCE, AND THE CLINICAL SEVERITY OF HEMIFACIAL SPASM , Volume 11 , Issue 11, November 2025, EPRA International Journal of Multidisciplinary Research (IJMR) , DOI: https://doi.org/10.36713/epra24895

🔗 PDF URL

https://cdn.eprapublishing.org/article/202511-01-024895.pdf

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