📄 Abstract
Chronotherapeutic is the timed administration of drugs according to the body’s internal clock which enhances the efficacy of the therapeutic and reduces the side effects of chrono pathological diseases like asthma, cardio-vascular diseases and rheumatoid arthritis among others [1,2]. There is a need for advanced drug delivery systems since the conventional dosage forms do not provide the intended time programmed or pulsatile release of drugs. Osmotic delivery systems for drugs (ODDS) are ideally strong systems, in which the drug release is controlled by osmotic pressure, independent of the surrounding fluid hydrodynamics and pH, hence predictable drug release [3,4]. It is in this regard that the book reviews the design, developmental evolution and formulation aspects of osmotic pumps for chronotherapeutic applications. The book provides an intricate evaluation of programmable drug delivery systems like push pull osmotic pumps (PPOP), time clock systems, capsule design, and multiarticulate osmotic systems with rupturable coating among others [5,6]. It also discusses the formulation factors including, the nature and number of osmotic agents, membrane’s porosity and thickness, and polymer dynamics, and laser-drilled orifice and their impact on lag time and subsequent drug release rates [7]. The book also reviews the FDA-approved formulations, in-vitro in-vivo correlation and clinical cases, challenges associated with the manufacture of osmotic pumps systems including dose dumping and scale-up issues, 3D printing technologies and future perspectives of osmotic pumps as smart systems for time programmed drug delivery [8].
🏷️ Keywords
📚 How to Cite:
Yashpal Singh Solanki, Tanisha Arora, Deepa Patwa, Harshveer Singh Jaitawat, Dr. Harshil Jagan , ADVANCEMENTS IN OSMOTIC DRUG DELIVERY SYSTEMS FOR CHRONOTHERAPEUTIC APPLICATIONS: DESIGN STRATEGIES, FORMULATION VARIABLES, AND FUTURE PERSPECTIVES , Volume 11 , Issue 9, September 2026, EPRA International Journal of Research & Development (IJRD) , Pages: 188 - 193 , DOI: https://doi.org/10.36713/epra29082