📄 Abstract
The present study focuses on the formulation and evaluation of mucoadhesive microcapsules containing acyclovir using different concentration of the naturally occurring natural polymer gelatin (1% to 6%); cross-linked with glutaraldehyde, using sodium alginate designed for oral controlled release. The drug acyclovir has been selected as suitable candidate for site specific delivery in stomach by encapsulating it in microcapsules because it has narrow absorption window, its oral bioavailability is poor (10-20%), its t1/2 is also less 2.5-3.3 hr. Due to these reasons dose of conventional ACV tablet 200mg (5 times a day), it is a typical task to administered tablet 5 times in a day, so there is need to develop to a suitable dosage form those increase the bioavailability of drug in body and reduce the dosing frequency. When the mucoadhesive microcapsules of ACV administered orally they adhere on stomach mucosa and will retain inside the stomach and release the drug continuously for prolong period of time in controlled release manner. It can maintain the adequate concentration of drug in body and ultimately increase the bioavailability of drug and gave batter therapeutic action as compared to other conventional dosage forms.
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📚 How to Cite:
Muskaan Rai, Dr Arun Kumar Patel, Mr. Shailendra Patel , DESIGN AND DEVELOPMENT OF ACYCLOVIR MICROSOMAL GEL , Volume 11 , Issue 7, July 2026, EPRA International Journal of Research & Development (IJRD) , Pages: 338 - 349 ,