📄 Abstract
The increasing emergence of drug-resistant microorganisms poses a significant challenge to public health worldwide. Therefore, there is a pressing need to develop novel antimicrobial agents with improved efficacy. The Isoxazole scaffold has shown promise as a potential antimicrobial agent. This study aims to synthesize a series of Isoxazole analogues and evaluate their antimicrobial activity. OBJECTIVE: Find out novelty by using software Scifinder. Synthesis and characterize the molecules which shows significant in- silico results. Assess the toxicity of the synthesized compounds. Evaluate biological efficacy of synthesized compounds for anti-bacterial activity using suitable in-vitro methods. METHODS: Ethyl acetoacetate and ammonium acetate was mixed with certain amount of corresponding aldehydes in methanol. The resulting mixture was left under reflux for 6 hours and the solid product formed was separated by filtration, purified by recrystallization from ethanol, washed with ethanol, and then dried. The compounds were further evaluated for their anti-bacterial activity. RESULTS: , 4-dihydro pyridine analogues were prepared by the reaction of ethyl acetoacetate was mixed with certain amount of corresponding aldehydes in of methanol. The resulting mixture was left under reflux for 6 hrs, and the solid product formed was separated by filtration, purified by recrystallization from ethanol, washed with ethanol and then dried. The compounds were tested for anti-bacterial activity against (staphylococcus aureus (+ ve), Escherichia coli (- ve), klebsiella pneumonia (- ve) and bacillus (+ ve). The synthesized compounds tested for anti-bac erial activity by the microbiological assay method. The compounds AB 1, AB 3, AB6 shown maximum zone of inhibition than the standard drug. CONCLUSION: In this work we have synthesized Isoxazole and our aim is to inspect these compounds against some kind of bacteria we have concluded that the synthesized compounds AB 1, AB 3, AB 6 have shown higher anti-bacterial activity compared to standard drug. This study aims to explore the antimicrobial potential of Isoxazole analogues. The results obtained from the synthesis and biological evaluation will contribute to the understanding of the structure-activity relationship and identify promising compounds for further development as antimicrobial agents. The development of novel and effective antimicrobial agents is crucial in combating the rising threat of drug-resistant microorganisms and improving global public health.
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📚 How to Cite:
P. Naveen Kumar, B. Sowdhamini, B. Jyothsna, B. Amulya , CH. Sravan Kumar , DESIGN & SYNTHESIS OF ISOXAZOLE DERIVATIVE FROM CHALCONES FOR ANTI MICROBIAL ACTIVITY , Volume 11 , Issue 7, July 2026, EPRA International Journal of Research & Development (IJRD) , Pages: 306 - 321 ,