📄 Abstract
Solid lipid nanoparticles (SLNs) have emerged as a promising nanocarrier system in modern drug delivery due to their ability to overcome limitations associated with conventional dosage forms. SLNs are submicron-sized particles composed of physiologically compatible lipids that remain solid at body temperature, offering a unique combination of advantages such as controlled drug release, improved bioavailability, and enhanced stability of encapsulated drugs. These carriers are particularly beneficial for poorly water-soluble drugs, enabling efficient drug loading and protection from degradation. The present review focuses on the development and characterization of SLN-based formulations for enhanced drug delivery. It comprehensively discusses various preparation techniques, including high-pressure homogenization, microemulsion methods, and solvent-based approaches, along with the role of formulation components such as lipids, surfactants, and stabilizers. Detailed insights into characterization parameters like particle size, zeta potential, drug entrapment efficiency, morphology, and in-vitro drug release are also provided. Furthermore, the review highlights the wide range of applications of SLNs in oral, topical, parenteral, ocular, and targeted drug delivery systems, including their potential in brain targeting and cancer therapy. Despite several advantages, certain limitations such as drug expulsion and low loading capacity are also addressed. In conclusion, SLNs represent a versatile and efficient platform for drug delivery, with significant potential for future advancements through surface modification, hybrid systems, and targeted delivery strategies. Continued research and technological innovations are expected to further enhance their clinical applicability and commercial viability.
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📚 How to Cite:
Satish Sudhakar Doifode , Prof Amol G Jadhao, Miss. Mayuri G. Zore , DEVELOPMENT AND CHARACTERIZATION OF SOLID LIPID NANOPARTICLE (SLN)-LOADED FORMULATIONS FOR ENHANCED DRUG DELIVERY , Volume 11 , Issue 4, April 2026, EPRA International Journal of Research & Development (IJRD) ,