📄 Abstract
In developing a concept called the Brain-Oral Axis, researchers are beginning to recognize that the brain and oral cavity communicate with one another and this two-way path between oral health and the brain could lead to better understanding of how oral disease affects brain function. Chronic periodontitis, for example, is now being considered an infection with systemic effects (not just effects on the mouth) based on its well-established links to neuroinflammation and conditions such as Alzheimer's disease and Parkinson's disease. Mechanisms involved in the Brain-Oral Axis include systemic inflammation, microbial translocation, and neural pathways, with some periodontal bacteria (like Porphyromonas gingivalis) potentially entering the bloodstream and causing damage to neurons by delivering virulence factors at the brain level; in addition, cytokines (produced during inflammation from periodontal infection) are believed to have the potential to cross or disrupt the blood-brain barrier, resulting in neuroinflammation. More recently, as researchers have begun studying the microbiome's influence on brain health, the Brain-Oral Axis has evolved into the oral-gut-brain axis where many microbes are interacting and may play a role in determining a person's risk of developing a neurological disorder. Currently, the extent of the association between periodontal disease and neurological disorders is well supported; however, research is underway to determine if these associations are the result of direct causation or other shared factors. Overall, understanding the Brain-Oral Axis will underline the role that oral health has on overall health and will help create new opportunities for preventative care and further interdisciplinary healthcare approaches.
📚 How to Cite:
Dr.Nimisha Mithradas, Dr.Archana.B, Dr.T.A.Lalitha, U.Thilak Ram, S.Vishwa , LINKING PERIODONTAL INFLAMMATION TO THE BRAIN: INSIGHTS FROM THE BRAIN–ORAL AXIS , Volume 11 , Issue 6, June 2026, EPRA International Journal of Research & Development (IJRD) , Pages: 309 - 315 ,